WellcomeTrust genome-wide association study of ischemic stroke.
نویسنده
چکیده
منابع مشابه
Results of a Genome-Wide Scan for Stroke Loci
Ischemic stroke has long been recognized to cluster in families. This clustering has been attributed to both genetic factors and common environmental exposures. Gene mutations have been identified that lead to rare ischemic stroke syndromes like CADASIL and MELAS. However, the search for genetic loci associated with ischemic stroke risk has yielded meager results thus far, despite several candi...
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BACKGROUND AND PURPOSE in a genome-wide association study and subsequent case-control studies, the single-nucleotide polymorphism rs12425791 on chromosome 12p13 was reported to be associated with ischemic stroke, but this could not be validated in a recent well-powered study. We therefore investigated whether an association between ischemic stroke and rs12425791 could be detected in 3 different...
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Stroke is one of the most common causes of death worldwide. Genetic risk factors have been found to play important roles in the pathology of ischemic stroke. In a previous genome-wide association study, a functional variant (rs9943582, -154G/A) in the 5' flanking region of the apelin receptor gene (APLNR) was shown to be significantly associated with stroke in the Japanese population. However, ...
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OBJECTIVE Rare mitochondrial mutations cause neurologic disease, including ischemic stroke and MRI white matter changes. We investigated whether common mitochondrial genetic variants influence risk of sporadic ischemic stroke and, in patients with stroke, the volume of white matter hyperintensity (WMHV). METHODS In this multicenter, mitochondrial genome-wide association study (GWAS), 2284 isc...
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ورودعنوان ژورنال:
- Stroke
دوره 44 6 Suppl 1 شماره
صفحات -
تاریخ انتشار 2013